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Michael S. Kolodney, MD, PhD Background Dr. Kolodney studied physics at MIT before completing his M.D.-Ph.D. at Washington University in St. Louis. He completed his dermatology and internal medicine residencies at UCLA. Dr. Kolodney joined the faculty at UCLA following his residency and moved to Harbor-UCLA in 2003. His clinical interests include targeted therapies for melanoma and the mechanism of corticosteroids in blistering diseases. Current projects in the lab are listed below: 1. Identification of biomarkers that predict melanoma sensitivity to kinase inhibitor therapeutics. 2. Development of PCR methods to identify minority mutations in clinical specimens. 3. Development of extremely high numerical aperture bioluminescence imaging systems 4. Clinical development of agents to selectively ablate adipose tissue. 5. The effects of corticosteroids on keratinocyte adhesion Recent Publications: 1. Collisson, E.A., Chen I.Y., Carranza, D and Kolodney, M. S (2002) Isoprenylation is Necessary for the Full Invasive Potential of RhoA Overexpression in Human Melanoma Cells. J. Invest. Derm. (2002) 119(5)1172-6 2. Collisson, EA, Kleer, C, Wu, M, De, A, Gambhir, SS & Kolodney, M.S. (2003) Atorvastatin Prevents RhoC Isoprenylation, Invasion and Metastasis in Human Melanoma Cells. Mol. Can. Ther. 2(10):941-8. 3. Collisson, EA, De, A, Gambhir, SS, Kolodney, M.S. (2003) Treatment of Metastatic Melanoma with a Small Molecule Targeted against Activating Mutations in the BRAF Gene. Cancer Res. 63(18):5669-73 4. Rotunda, R.M., Suzuki, H., Moy, R.L..and Kolodney, M.S., (2004) Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidylcholine formulation used for localized fat dissolution. Derm. Surg. 30(7):1001-8 5. Iqbal, M and Kolodney, M.S. (2005) Acne Fulminans with SAPHO syndrome treated with infliximab. J. Amer. Acad. Derm. J Am Acad Dermatol. 52 (5) :S118-20 6. Rotunda, AM & Kolodney MS (2005) Lipomas treated with subcutaneous deoxycholate injections J. Amer. Acad. Derm 53:973-8 7. Dominguez, PL and Kolodney, MS (2005) Wild-type blocking polymerase chain reaction for detection of single nucleotide minority mutations from clinical specimens Oncogene 24(45):6830-4 8. Rotunda, AM & Kolodney, MS (2005) “Mesotherapy” and Phosphatidylcholine Injections: Historical Clarification and Review. Derm. Surg. 32(4):465-480 |
Department of Dermatologyy
1000 W. Carson Street, Box 25
Torrance, California 90509